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2025 American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU 2025)

13 February - 15 February, 2025, United States

Adjuvant nivolumab delivers in muscle-invasive bladder cancer

2025-03-24

Adjuvant nivolumab appears to improve survival outcomes in patients with muscle-invasive bladder cancer (MIBC) who have undergone radical surgery, regardless of prior exposure to neoadjuvant chemotherapy, according to additional data from the phase III CheckMate 274 trial.
Oestradiol patches bump up ADT armamentarium for prostate cancer

2025-03-24

Findings from a phase II trial demonstrate the potential of transdermal oestradiol (tE2) patches as androgen deprivation therapy (ADT) for men with metastatic (M1) prostate cancer who are on androgen receptor pathway inhibitors (ARPI).
EV-302 2-year updates: EV+P maintains transformative benefit in bladder cancer

2025-03-24

The updated analysis of the phase III EV-302 trial continues to show the benefit of front-line enfortumab vedotin plus pembrolizumab (EV+P) compared with chemotherapy in patients with previously untreated locally advanced or metastatic urothelial carcinoma (la/mUC).
Efficacy benefit of nivolumab plus cabozantinib combo in aRCC continues through final results

2025-03-24

The long-term efficacy benefit of the nivolumab and cabozantinib combination vs sunitinib as a frontline treatment for aRCC is observed through the final results of CheckMate 9ER, with the report covering a minimum follow-up of 5 years first presented at ASCO GU 2025
Survival in mCRPC prolonged with talazoparib?enzalutamide combo

2025-03-24

The combination of the PARP inhibitor talazoparib plus the androgen receptor-pathway inhibitor enzalutamide yields a clinically meaningful increase in the overall survival of patients with metastatic castration-resistant prostate cancer (mCRPC) being treated in the first-line setting when compared with enzalutamide alone, according to final data from the phase III TALAPRO-2 trial.
Mevrometostat plus enzalutamide improves outcomes in mCRPC patients

2025-02-28

Treatment with mevrometostat (MEV), an enhancer of zeste homolog 2 inhibitor, in combination with enzalutamide (ENZ) results in better survival outcomes and response than ENZ alone among patients with metastatic castration-resistant prostate cancer (mCRPC), reports a study presented at ASCO GU 2025. The combined therapy also demonstrates a favourable safety profile.
ARANOTE: Darolutamide plus ADT delays progression in patients with mHSPC

2025-02-28

The use of darolutamide (DARO) in addition to androgen deprivation therapy (ADT) is effective at improving radiological progression-free survival (rPFS) in patients with metastatic hormone-sensitive prostate cancer (mHSPC) compared with placebo plus ADT, irrespective of disease volume, according to the subanalysis of the phase III ARANOTE trial.

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